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Estimating drug/plasma concentration levels by applying neural networks to pharmacokinetic data sets

Tolle, Kristin M. and Chen, Hsinchun and Chow, Hsiao-Hui (2000) Estimating drug/plasma concentration levels by applying neural networks to pharmacokinetic data sets. Decision Support Systems, Special Issue on Decision Support for Heath Care in a New Information Age 30(2):pp. 139-152.

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Abstract

Predicting blood concentration levels of pharmaceutical agents in human subjects can be made difficult by missing data and variability within and between human subjects. Biometricians use a variety of software tools to analyze pharmacokinetic information in order to conduct research about a pharmaceutical agent. This paper is the comparison between using a feedforward backpropagation neural network to predict blood serum concentration levels of the drug tobramycin in pediatric cystic fibrosis and hemotologic–oncologic disorder patients with the most commonly used software for analysis of pharmacokinetics, NONMEM. Mean squared standard error is used to establish the comparability of the two estimation methods. The motivation for this research is the desire to provide clinicians and pharmaceutical researchers a cost effective, user friendly, and timely analysis tool for effectively predicting blood concentration ranges in human subjects.

EPrint Type:Journal Article (Paginated)
Keywords:National Science Digital Library, NSDL, Artificial Intelligence Lab, AI Lab, Medical applications
Subjects:Artificial Intelligence
ID Code:512
Deposited On:13 October 2004
Alternative Locations:http://ai.bpa.arizona.edu/go/papers.html
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